Combination with Insulin with or without Metformin In a 26-week double blind trial (Trial 6, NCT03021187), 731 adult patients with type 2 diabetes mellitus inadequately controlled on insulin (basal, basal/bolus or premixed) with or without metformin, were randomized to RYBELSUS 3 mg, 7 mg and 14 mg once daily or placebo once daily
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Results confirmed that DRS remained significantly associated with overall survival even after adjusting for other clinical variables, including WHO grade, age at diagnosis, radiotherapy status, chemotherapy status, and 1p/19q codeletion status