In the absence of a gold standard normalization method, it appears to be good practice to use multiple normalizers showing low variation within the samples
People with type 2 diabetes typically lose less weight on incretin therapy than people without it, so this trial is the one that shows what retatrutide does in the harder population
They target different metabolic bottlenecks
(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents
This meta-analysis revealed that L-carnitine supplementation significantly reduces levels of triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), HbA1c, HOMA-IR, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-), as well as weight, body mass index (BMI), body fat percentage (BFP), and leptin in patients with diabetes and impaired glucose tolerance