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Eur J Clin Microbiol Infect Dis 28:13531356

The Potential Benefits of Coffee Enemas Despite the limited evidence, proponents of coffee enemas tout various purported benefits, including: Detoxification : Advocates believe coffee enemas can enhance liver detoxification and promote the elimination of toxins

Patients treated for dehydration from illness, exertion, or hangovers often feel immediate relief, including less dizziness, improved headache, and better thirst control within the same day

doi: 10.1203/00006450-197608000-00009 35 HolmesBDayNHasemanJGoodRA

The foundational characterisation comes from Raun et al., 1998, who described ipamorelin as "the first selective growth hormone secretagogue." In the taxonomy of research peptides, ipamorelin therefore sits between the older, less selective compounds such as GHRP-2 and GHRP-6 on one side and the GHRH analogues such as CJC-1295 or tesamorelin on the other