Melanotan I (also known as afamelanotide) acts on MC1R and has increased resistance to enzymatic breakdown, whereas melanotan II is a shorter cyclic variant that increases pigmentation at a lower cumulative dose and is less specific and more lipophilic, thereby crossing the blood-brain barrier more easily, leading to more widespread adverse effects
That said, we can draw some conclusions about PT-141s safety from the relatively little research available to us
when you turn on growth and repair pathways, you may also be lighting a fuse for uncontrolled growth like cancer
doi:10.1074/jbc.M605850200
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