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The antioxidant curcumin alleviates Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-B axis and activating NRF2-induced HO-1 expression
Although IL-17, as a hallmark cytokine of T H 17 cells, plays critical roles in the pathogenesis of autoimmune diseases, targeting IL-17 alone with anti-IL-17 antibodies was not sufficient to improve clinical end points (54)
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Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells
53 In addition, KRAS and USP1 can also regulate the expression of BCAT2 in PDAC through the ubiquitin-proteasome pathway: KRAS can stabilize the expression of BCAT2 in PDAC by inhibiting the ubiquitination of BCAT2 by spleen tyrosine kinase (SYK) and E3 ubiquitination ligase TRIM21, 54 while USP1 deubiquitinates the K229 site of BCAT2, and BCAAs promote USP1 protein expression at the translation level through the GCN2-eIF2a pathway
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