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cGKI-deficient mice are characterized by enhanced eryptosis, anemia, and splenomegaly with accumulation of PS-exposing erythrocytes in the spleen [175]
27 DesagherS.MartinouJ
Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes