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Graphical abstract Similar content being viewed by others Introduction Sodiumglucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to reduce the incidence of cardiovascular and kidney disease in people with type 2 diabetes, ostensibly independent of their effects on blood glucose [1, 2]

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A comprehensive analysis of the known effects of GLP-1 and GLP-1RAs on cognitive, cellular, and molecular changes in NDD in preclinical and clinical studies have shown that both natural GLP-1 and its analogues, GLP-1RAs (dulaglutide, exenatide, liraglutide, lixisenatide, semaglutide, and tirzepatide) improve cognitive and motor functions

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