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With the progression of HT, these imbalances intensify further, with a substantial decline in beneficial bacteria and heightened dominance of pathogenic bacteria, including Streptococcus , Enterobacteriaceae and Acinetobacter (Sessa et al., 2025)

Importantly, elimination of this radiation-induced G2/M blockade is a promising radiosensitising approach as cancer cells frequently have a deficient G1 checkpoint (60, 61)

This study was supported by Grants NIH R35GM141478, VA 1I01BX004639 and VA I01BX006408 (to X-AL)