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An analysis of the mechanism reveals that the nanoparticles facilitate the oxidation of GSH into GSSG, leading to disruptions in redox balance and the antioxidant defense system and therefore accumulation of ROS and lipid peroxides

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Ubiquitous epigenetic silencing of GSTP1 in PCa leads to increased survival and accumulation of potential priming DNA conjugates after exposure to long-term oxidative damage, suggesting that GSTP1 has protective and antitumor functions (40)