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Glucose-dependent insulinotropic polypeptides add a second mechanism of action which affects the breakdown and transport of fat, which ultimately leads to lower body fat and weight loss

Overall, these differing receptor interaction patterns of GLP-1 and oxyntomodulin were associated with larger conformational dynamics within the oxyntomodulin binding pocket during the course of the MD simulation, with the cavity opening and closing, likely due to the lack of stable interactions within the base of the TMD binding pocket, TM2 and ECL2, coupled with more persistent interactions with the upper regions of TM1 and TM7, relative to GLP-1 (Fig

Shao et al., 2022

Zhang T, Qi Y, Liao M, Xu M, Bower KA, Frank JA, Shen HM, Luo J, Shi X, Chen G (2012) Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation

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