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A long-term study of istradefylline safety and efficacy in patients with Parkinson disease

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2 King et al in a large-scale survey reported that oral pigmented nevi are a rare entity found only in 0.1% of the patients and coined a specific term, intramucosal nevus

However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

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