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doi: 10.1097/PAI.0000000000001148 52

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10.1016/j.csm.2024.12.006 3 CaoS.WeiY.XuH.WengJ.QiT.YuF.et al (2023)

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Results indicate that DA-JC1 reduces neuroinflammation by inhibiting the proliferation of astrocytes and microglia in the substantia nigra, and mitigates the damage of toxic substances MPTP to midbrain dopaminergic neurons and fibers by promoting the expression of BDNF, phosphorylation of Akt in the PI3K/Akt signaling pathway, downregulating the pro-apoptotic protein Bax, and upregulating the anti-apoptotic protein Bcl2 ( .An experiment applied a second-generation novel GLP-1/GIP dual receptor agonist, DA3-CH, to an MPTP-induced Parkinsons mouse model and compared its neuroprotective effects with the GLP-1 single receptor agonist, liraglutide