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Of note, our previous work demonstrated that the gut metabolite NaB markedly reversed HFD-induced dysbiosis of the gut microbiota in mice and significantly elevated the abundance of Lactobacilli in the gut 10 , which supported the hypothesis that NaB might have the potential to improve GLP-1 resistance

We chose to focus on SLC7A11 as playing a critical role in intracellular GSH levels, targeting SLC7A11 with erastin

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We attribute the lower Rac1GTP levels to several factors, including immunosuppression, an increased population of immature neutrophils (pandemic) in some patients, and pathogen-induced depletion of neutrophils (neutropenia) in others (Seigel et al., 2012

This is not a reason to dismiss every compounded option, but it is a reason to approach this space carefully