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In addition, Nrf2 enhances the de novo GSH synthesis in response to oxidative insults [3,4]

(IV) The metal nanomedicines show great potential for cancer therapy not only because of the capability of GSH exhaustion, but also for their wide range of other biological effects, such as interference with osmotic pressure, regulation of the immune system, and activation of biocatalysis ( in vivo metabolism and excretion behavior of metal nanomedicines should also be conducted

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doi: 10.1007/978-1-4939-2845-3_3 58 BakDWBechtelTJFalcoJAWeerapanaE

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