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The body obtains B12 exclusively from animal-based foods such as meat, fish, dairy products, and eggs, or from fortified foods and supplements

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We have proposed that this effect is mediated by activation of the few GLP-1 receptors present in -cells and that this, via a small increase in cAMP, results in inhibition of the voltage-gated Ca 2+ channels linked to exocytosis of glucagon-containing secretory granules

The degree of these effects may influence nausea severity, with more potent agents or higher doses typically associated with more pronounced effects