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GSH availability downregulates the pro-inflammatory potential of leukotrienes and other eicosanoids

Free fatty acids from either adipose tissue (fat), or from the conversion of excess carbohydrate intake, accumulate in the liver cell resulting in oxidative stress, inflammation, and liver injury

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Definitive genetic validation using MT1- or MT2-deficient ILC2s remains an important next step in confirming that melatonin acts on ILC2s independent of canonical melatonin receptors

Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, et al