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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918
it is banned at all times, in and out of competition, for athletes subject to anti-doping codes, and is not classified under S2 (Peptide Hormones, Growth Factors, and Related Substances), which is reserved for specifically defined peptide hormones and growth factors such as hGH and EPO
It is undeniable that AS is a chronic inflammatory disease, and inflammation is constantly induced throughout the course of the disease (Ross, 1999
The slight elevation of homocysteine observed in our study is unexpected since serine and folate lower homocysteine levels in individuals with hyperhomocysteinemia 37,38
