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Recent sequencing studies have identified significant alterations in NRAS, BRAF, NF1, KIT, SF3B1, TP53 , and SPRED1 , informing potential targeted therapeutic strategies for MM (160, 161)

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Phase 3 Update: TRIUMPH-4 Results Preliminary data from the ongoing Phase 3 TRIUMPH-4 trial (68 weeks) shows higher numbers than Phase 2: 12mg dose: 28.7% average weight loss (~71 lbs / 32 kg) 9mg dose: 26.4% average weight loss (~64 lbs / 29 kg) Knee osteoarthritis pain: 76% reduction (significant quality-of-life improvement) Blood pressure: Average reduction of 14 mmHg Full Phase 3 results across the TRIUMPH program (obesity, diabetes, cardiovascular outcomes, kidney outcomes) are expected throughout 2026

1,12 Otherwise, the presence of residual cancer cells after surgery can lead to cancer recurrence and poor prognosis