semaglutide recombinant synthesis Synthetic Routes Structure of semaglutide (subcutaneous formulation)

Owner: SINOPEP ALLSINO BIOPHARMACEUTICAL CO LTD Method for purifying sermaglutide The invention discloses a method for purifying sermaglutide

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In an aspect, expression vector that is used in the process of the present invention can be commercially available expression vectors or custom designed vectors selected from pET vectors, pd451sR and the like

After the reaction, the acetonitrile was removed by rotary evaporation, an appropriate amount of ethyl acetate was added to dissolve the product, and 4% NaHCO was used for each

As an embodiment of the invention, R in the compound 1 and the compound 4 is tert-butyl, and the specific synthetic route I' is as follows: wherein, the substituent R in the compound 1, the compound 2 and the compound 4 is tert-butyl