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N., Stoletov, K., Yuan, Q., Bera, K., et al
What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
Macrophages and intestinal epithelial cells play critical roles in iron metabolism, which can mediate ROS generation (121)
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[CrossRef] [PubMed] [Google Scholar] Prenatal effects of retinoic acid on lumbar spinal cord development and liver antioxidants in rats
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