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A key data point for researchers is the "responder rate." In the retatrutide Phase 2 trial, 100% of the participants in the 8 mg and 12 mg dose groups achieved a weight reduction of at least 5%

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If a lack of vitamin B12 prevents the brain from making these chemicals, you may experience common depressive symptoms, like: Anxiety Irritability Sadness Restlessness Additionally, a B12 deficiency can: Lead to increased amounts of the amino acid homocysteine, which can make depression worse [9]