Vitamin B12 (cobalamin) is a water-soluble vitamin essential for neurological function, DNA synthesis, and red blood cell formation
Related studies mainly focus on in vivo intervention efficacy validation, exploration of combined intervention strategies, and optimization of pharmaceutical dosage forms, providing important experimental evidence for clinical intervention of obesity
In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself
How will progress be measured, and over what timeframe
MOTS-c, being a peptide, is primarily studied through subcutaneous injection to ensure it reaches systemic circulation effectively
