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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )
A persons natural glutathione levels fluctuate constantly throughout the day, dipping lowest in the morning and decreasing with age
Similarly, 125 metabolites were significantly upregulated and 64 metabolites were significantly downregulated in the ESC group compared with the CON group (Fig
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