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The FDA expanded semaglutide's (Wegovy) use to reduce the risk of cardiovascular death, heart attack, or stroke in adults with cardiovascular disease and overweight or obesity, based on a cardiovascular outcomes trial in which it reduced major adverse cardiovascular events by 20% compared with placebo

Some products may contain added sugars or artificial flavors, which could counteract the weight loss benefits

Corticosteroid-induced weight can be stubborn, and the anti-inflammatory benefits may precede visible weight changes

This had been devised as part of an attempt to transplant pancreases into people with severe type 1 diabetes

doi: 10.31838/IJPR/2020.12.04.125 200