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For example, siTGF-PLP-Nesn anoparticles composed of neutrophils (NEs) and cationic liposomes carrying paclitaxel/TGF- (TGF-) siRNA, can also target tumor sites and prevent tumor-associated neutrophils from transitioning from an anti-tumor (N1) phenotype to a pro-tumor (N2) phenotype thereby enhancing anti-tumor immunity and inhibiting tumor growth (114)

The dosage and frequency of use will be determined based on the specific condition being treated

Ionomycin was used as a positive control

A major limitation of metabolomics is the great heterogeneity associated with the biological composition of distinct metabolites

Studies in the AOP provide evidence of upstream KEs observed at the same doses or lower doses as the downstream KEs