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Cerebrospinal fluid concentrations rise within approximately 30 minutes of an intranasal dose and are reported to reach roughly 60 to 70 percent of corresponding plasma concentrations in rodent studies, a striking ratio for a peptide of this size

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High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial

Importantly, these changes were observed without significant reductions in food consumption, pointing to enhanced energy metabolism rather than appetite suppression as the primary mechanism

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