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The acquired raw images for each sample were preliminarily processed using the IDEAS software platform (Version 6.2, EMD Millipore) to remove out-of-focus cells, artifacts, debris, and clumped objects, and finally saved in.tif format for downstream deep-learning analysis 11,23,58

Table 8 shows a list of NE inhibitors that have shown therapeutic potential or are being explored in emphysema treatment [16,141,142,143,144,145]

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