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Each additional receptor target has produced incrementally better results in trials, though no direct head-to-head studies exist yet

However, the specific interactions depend on concentration and formulation details

doi: 10.1016/j.celrep.2014.10.032 68 GrassetEPuelACharpentierJColletXChristensenJETercFet al

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The data show that the drugs have a wide array of beneficial effects but not without risks, Ziyad Al-Aly , MD, FASN , an assistant professor of medicine at the Washington University School of Medicine in St