2025 Feb 23;14(3):256
302 Diethyl fumarate (DMF), an activator of Nrf2, has been reported to reduce lipid peroxidation and inhibit hepatocyte ferroptosis, thereby ameliorating alcoholic hepatitis
Baraska A, Woniak A, Mokra K, Michaowicz J
Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]
Dans des conditions physiologiques normales, jusqu' environ 90 98 % du glutathion cellulaire se trouve sous la forme rduite GSH, et une augmentation des niveaux de GSSG est largement utilise comme indicateur de stress oxydatif et de dtrioration de la sant cellulaire