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Notably, ARA 290 appears to improve symptoms of SFN, as assessed by the SFNSL, as well as on quality of life, as assessed by the pain and physical functioning dimensions of the SF-36

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Generalized pain, particularly leg pain, after B12 injection is common since its typically given in that location

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However, the correlation with BMI, Waist circumference, Glucose, HbA1c, Insulin, HOMA-IR index, triglycerides (TG), total cholesterol (TC), Low-density lipoprotein-cholesterol (LDL-C), Systolic BP, C-reactive protein (CRP) and Serum folate was insignificant or weak