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In addition, using co-culture of the HT-NETs model and Nthy-ori3-1 cells, we showed that histidine inhibits the expression of pro-inflammatory cytokines TNF and IL-6 and increased antioxidant enzyme SOD synthesis in Nthy-ori3-1 cells through suppression of the NF-B pathway

Patients on multiple anticonvulsants, children, those with congenital metabolic disorders, those with severe seizure disorders accompanied by mental retardation, and those with organic brain disease may be at particular risk

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The peptide appears to exert effects through upregulation of VEGF (angiogenesis), activation of FAK/paxillin pathways (cell adhesion and proliferation), stimulation of nitric oxide synthesis (cytoprotection), and increased growth hormone receptor gene expression

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