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The independent effects included in the model were treatment, region, strata (renal function for PIONEER 5 and insulin regimen for PIONEER 8), background medication and interaction between treatment and background medication as categorical fixed effects and baseline value as a covariate, all nested within visit, and using an unstructured residual covariance matrix

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Tear the paper tab off a new needle, push and twist it onto the pen until snug, then remove both needle caps

Diabetes Care , 46 (12), 2252-2262

Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky