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Immune reaction: Peptides can trigger antibody formation or hypersensitivity, which could complicate assisted reproduction or pregnancy if immune balance is shifted

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Stratikopoulos and colleagues 21 produced a mouse model in which IGF-I cDNA is regulated under a native promoter/enhancer of IGF-I gene only in liver on an Igf1 null background, and revealed that endocrine IGF-I contributed approximately 30% of the adult mouse body size

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They reduce appetite but they dont fix the behaviours that caused metabolic dysfunction in the first place