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Clinically, both specific ferroptosis inhibitors (such as Ferrostatin-1) and traditional medicine components (such as Puerarin) have emerged as promising therapeutic candidates, showing cardioprotective effects in experimental models

Indeed, iron-dependent neuron loss was described in -synucleininduced neuronal death well before the emerging concept of ferroptosis (6), though evidence linking lipid peroxidation, ferroptosis, and synucleinopathy has been lacking

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