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PR3-ANCA bind and cross-link mPR3 (137) on neutrophils, thereby initiating, together with Fc receptor engagements (138, 139), intracellular mitogen-activated protein kinase (140), Syk tyrosine kinase (141), and phosphoinositide 3-kinase/Akt (142, 143), signaling and subsequently cell activation

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[22] [23] [25] [30] This became known as the Zimmerman-McLean-Foster Hypothesis. Although this hypothesis sparked controversy regarding the safety of enucleation, it also inspired new surgical techniques, such as the no touch enucleation, and encouraged the use of globe-salvaging therapies such as radiation and laser therapies

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