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4 ) Neurodegeneration, which is linked to a decline in NAD + concentrations in the brain, is closely associated with aging and various neurodegenerative disorders

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In a 2022 animal study examining infected diabetic wounds, doses up to 5 mg/kg showed no hepatotoxicity or renal impairment.(pubmed.ncbi.nlm.nih.gov) Copper overload risk: Chronic high doses could, in theory, raise serum copper and lower zinc, leading to nausea or neurologic symptoms