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The etiology of vitamin D deficiency can be attributed to a multitude of factors, including aging, inadequate engagement in outdoor activities, excessive use of sunscreen, inadequate vitamin D supplementation, obesity, high latitudes, and diet [14]

Both transcellular mechanisms seem to be mediated by tumor necrosis factor alpha (121, 123)

Steiner HL 3rd, et al

KPV (Lys-Pro-Val), a tripeptide with anti-inflammatory properties, demonstrates higher local tissue concentration when administered SubQ near the target site (e.g., abdominal SubQ for gut inflammation studies) compared to IM deltoid, which distributes systemically without site preference

Sleep studies also revealed that oxidative stress affects the length and depth of our sleep