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By activating autophagy, Astragaloside IV prevents activation and assembly of NLRP3 inflammasome and reduces the release of pro-inflammatory cytokines in the liver and kidneys injured by CP (Qu et al., 2019)

Emerging paradigms: novel mechanisms and druggable targets Beyond these established pathways, recent discoveries have unveiled novel mechanistic layers and therapeutic targets, expanding the intervention landscape for mitochondrial optic neuropathies

To functionally confirm that PA-treated SUM-159 cells undergo ferroptosis, we evaluated the expression of the transferrin receptor 1 (TfR1), which is responsible for iron delivery to cells

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Curr Aging Sci