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Peptides came up as one class under investigation because some play roles in immune regulation, tissue repair, and hormone signaling

This implies that DPP4is, characterized by their small molecular size (below 500 Da), can effectively hinder the enzyme's catalytic site, inhibiting its function, while preserving the molecule's capacity to act as a costimulatory factor without disruption

Sitagliptin: A review of its use in the management of type 2 diabetes mellitus

Blood transfusion improves the oxygen-carrying capacity and improves microvascular perfusion by decreasing the HbS percentage

Nevertheless, sulphasalazine has been demonstrated to be an effective treatment in cancer models, by inhibiting xCT to activate ferroptosis 232,233 and restore sensitivity to chemotherapy