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10.2337/db09-1694 4 AravindhanK.BaoW.HarpelM

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contains only 2-5% curcuminoids by weight Supplement curcumin risk / moderate to high at doses above 500 mg daily Piperine (BioPerine) effect / amplifies curcumin bioavailability up to 2,000%, compounding interaction risk Dose separation window / at least 2 hours between curcumin supplement and amlodipine Monitoring needed / home blood pressure checks twice daily for the first 2 weeks after adding curcumin Most common adverse signal / orthostatic hypotension, ankle edema, headache Who should avoid combining / patients on amlodipine 10 mg, those with baseline systolic BP below 110 mmHg, or anyone co-prescribed other CYP3A4 inhibitors Why This Interaction Matters Amlodipine is the most widely prescribed calcium channel blocker in the United States, with over 88 million dispensed prescriptions in 2022 according to ClinCalc drug usage statistics

Results were published in the Journal of the American College of Cardiology

PMID: 40893681 Cell Death Discov2023 Dec 19;9(1):464