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This observation suggests that GSH has no cytotoxic effect on HepG2 cells at concentrations below 1 mM

However, this result is expected considering the very high activity of glutaredoxins as deglutathionylating enzymes and a decreased GSSR concentration neither excludes mechanism (ii) or (iii) from Fig

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GDNF exerts its protection by binding to the GDNF family receptor -1 (GFR) and c-Ret receptor complex, thereby maintaining the function and survival of dopaminergic neurons [234236]