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doi: 10.1007/s00018-012-1176-1, 43

Characterized by an excessive accumulation of fat that impairs health, obesity increases the risk of developing serious comorbidities, such as cardiovascular disease, type 2 diabetes, musculoskeletal disorders, certain cancers, and psychological disorders (3, 4)

Conclusion In general, women with PCOS develop IR owing to abnormal insulin signalling and metabolic dysfunction in insulin-responsive tissues, with a high incidence of IR in PCOS and a significant negative impact on health

Obesity (Silver Spring, Md.), 31(1), 111122