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Recent studies also identified Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) as key mechanoresponsive factors in the Hippo pathway to transmit blood flow-induced mechanical forces into intracellular signaling to affect EC phenotypes [223]

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This raises an important question about long-term use that does not have a clean answer yet

Xie W, Deng Y, Chen S, Wu Y, Li Y, Yang Q