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CIT produced no significant changes in aortic or brachial pressures, pulse pressure, heart rate, augmentation index, or carotid-femoral pulse wave velocity

Rare but serious side effects include pancreatitis (0.1% of users, usually in those with personal or family history) and thyroid complications (monitor if family history of thyroid disease exists)

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Study populations ranged from small, single-center clinical cohorts to large administrative registries including up to 61,927 participants