januvia and glp-1 together sitagliptin [TUSOM These highlights do not include

Conclusions The result of this meta-analysis demonstrates that compared to sitagliptin, GLP-1 analogues are more effective for glycemic control and weight loss, but have similar efficacy in reducing blood pressure and lipid parameters, however, GLP-1 analogues are associated with a higher incidence of gastrointestinal adverse events and a similar incidence of hypoglycemia compared to sitagliptin

What Rapamycin does Targets mTOR : Rapamycin blocks a protein complex called mTOR, which acts like a control center for cell growth, metabolism and aging

The effect often eases once the dose drops

doi:10.1016/j.diabres.2006.07.005 [DOI] [PubMed] [Google Scholar] 37.Karkabounas S, Papadopoulos N, Anastasiadou C, et al

However, it can lead to some severe complications, including: Severe malnutrition or dehydration from consistent nausea or from the bodys failure to absorb nutrients from food Bezoars (hardened masses of undigested food in the stomach), which can prevent all food from passing through the stomach and into the small intestine, which could a life-threatening situation Erratic changes in bloods sugar levels , which can not only affect ones diabetes, but can also lead to neurological disorders, thyroid diseases, kidney diseases and obesity. Other potential complications/ conditions associated with Ozempic and Mounjaro include thyroid tumors (listed on Ozempics Black Box warning) cancer, gallbladder diseases/gallstones, pancreatitis, kidney failure, and changes in vision