next gen glp 1 9 Companies Developing Next-Generation GLP-1 Drugs GLP-1-based therapies for diabetes, obesity

The margin between therapeutic and problematic doses in GLP-1 class peptides is relatively wide, but that does not excuse careless calculation

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These agents have multiple effects relevant to brain health: improved glycemic control (lowering glucose spikes, avoiding hyperglycemia) weight loss, which reduces many risk factors (vascular disease, hypertension, dyslipidemia) possible reduction of systemic inflammation possible direct neural effects: crossingor affectingthe blood brain barrier

semaglutide is FDA-approved for chronic weight management

These results were paralleled in rats (Supplementary Figure 2A), demonstrating across species that GLP-1R activation diminishes the cocaines ability to increase extracellular DA in the LS