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In March 2026, one of the core semaglutide composition patents expired

Comparative Trials of Glucagon-Like Peptide-1 Inhibitors and ActRII Inhibitors Clinical trials comparing GLP-1 RAs like semaglutide and dual incretin agonists (GLP-1RA/GIP) like tirzepatide, alone or in combination with myostatin inhibitors (bimagrumab, trevogrumab, and garetosmab), demonstrate varying effects on weight loss, body composition, and physical function in obese populations , (Table 2)