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Prothymosin alpha plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms

Additionally, GLP-1 therapy improves insulin sensitivity and reduces inflammation markers in some patients, which may indirectly support fibromyalgia management since insulin dysregulation and inflammatory pathways are implicated in fibromyalgia pathogenesis

Scientists found that a natural gut hormone, glucagon-like peptide-1 (GLP-1), helps control blood sugar by stimulating insulin, slowing digestion, and signaling fullness to the brain

Notably, lactylation also acts as a key mediator for some drugs in cerebral IRI protection, such as Buyang Huanwu Decoction, which effectively inhibits cerebral IRI deterioration by suppressing extensive lysine lactylation and specific H3K18 lactylation [117]

This hypothesis is a result of the discovery that GPX4 inactivation-induced ferroptosis is caused mostly by nonmitochondrial lipid peroxidation [66]