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To examine the nitric oxide-dependency in this system, the rings were pretreated with 0.03 mM L-NAME, an eNOS inhibitor or 10 M hemoglobin, a nitric oxide scavenger

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The difference in HbA1c reduction between the two groups was statistically significant ( P = 0.03), indicating a slightly greater effect of GLP-1 agonists in improving glycemic control