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there was no significant difference in either body-weight gain or total food intake (per g body weight) among four experimental groups (data not shown)

In this respect, it is noteworthy that PO primarily predisposes to childhood obesity through complex biological mechanisms (e.g., genetic inheritance, induction of adverse metabolic programming), but also by influencing deleterious lifestyle habits (e.g., children grown by families with obesity frequently have sedentary behaviors and overeating-type eating styles)

For many drug effects, the response increases with increase in dose, with low sub-therapeutic doses giving an inadequate response, therapeutic doses giving the desired response, but very high doses giving an excessive response that can be regarded as a form of toxicity (response 1 in Fig

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